Dexamethasone induces the expression of LRRK2 and α-synuclein, two genes that when mutated cause Parkinson’s disease in an autosomal dominant manner

LRRK2 (leucine-rich repeat kinase 2) has been identified as a gene corresponding to PARK8, an autosomal-dominant gene for familial Parkinson’s disease (PD). LRRK2 pathogenicspecific mutants induce neurotoxicity and shorten neurites. To elucidate the mechanism underlying LRRK2 expression, we construc...

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Detalhes bibliográficos
Main Authors: Park, Ji-Min, Ho, Dong-Hwan, Yun, Hye Jin, Kim, Hye-Jung, Lee, Chan Hong, Park, Sung Woo, Kim, Young Hoon, Son, Ilhong, Seol, Wongi
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society for Biochemistry and Molecular Biology 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133879/
https://ncbi.nlm.nih.gov/pubmed/24064060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2013.46.9.234
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