Liver Tumor Promotion by 2,3,7,8-Tetrachlorodibenzo-p-dioxin Is Dependent on the Aryl Hydrocarbon Receptor and TNF/IL-1 Receptors

We set out to better understand the signal transduction pathways that mediate liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxn (“dioxin”). To this end, we first employed congenic mice homozygous for either the Ahr(b1) or Ahr(d) alleles (encoding an aryl hydrocarbon receptor (AHR) with hig...

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Hauptverfasser: Kennedy, Gregory D., Nukaya, Manabu, Moran, Susan M., Glover, Edward, Weinberg, Samuel, Balbo, Silvia, Hecht, Stephen S., Pitot, Henry C., Drinkwater, Norman R., Bradfield, Christopher A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Molecular Toxicology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133587/
https://ncbi.nlm.nih.gov/pubmed/24718703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu065
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