A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy

Studies have endeavored to reconcile whether dysfunction of neutrophils in people with cystic fibrosis (CF) is a result of the genetic defect or is secondary due to infection and inflammation. In this study, we illustrate that disrupted function of the CF transmembrane conductance regulator (CFTR),...

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Detalhes bibliográficos
Main Authors: Pohl, Kerstin, Hayes, Elaine, Keenan, Joanne, Henry, Michael, Meleady, Paula, Molloy, Kevin, Jundi, Bakr, Bergin, David A., McCarthy, Cormac, McElvaney, Oliver J., White, Michelle M., Clynes, Martin, Reeves, Emer P., McElvaney, Noel G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133506/
https://ncbi.nlm.nih.gov/pubmed/24934256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-02-555268
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