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Plasmacytomagenesis in Eμ-v-abl transgenic mice is accelerated when apoptosis is restrained
Mice susceptible to plasma cell tumors provide a useful model for human multiple myeloma. We previously showed that mice expressing an Eµ-v-abl oncogene solely develop plasmacytomas. Here we show that loss of the proapoptotic BH3-only protein Bim or, to a lesser extent, overexpression of antiapoptot...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4133484/ https://ncbi.nlm.nih.gov/pubmed/24986687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-570770 |
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