ICOS-based chimeric antigen receptors program bipolar T(H)17/T(H)1 cells

With the notable exception of B-cell malignancies, the efficacy of chimeric antigen receptor (CAR) T cells has been limited, and CAR T cells have not been shown to expand and persist in patients with nonlymphoid tumors. Here we demonstrate that redirection of primary human T cells with a CAR contain...

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Main Authors: Guedan, Sonia, Chen, Xi, Madar, Aviv, Carpenito, Carmine, McGettigan, Shannon E., Frigault, Matthew J., Lee, Jihyun, Posey, Avery D., Scholler, John, Scholler, Nathalie, Bonneau, Richard, June, Carl H.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2014
主題:
Gene Therapy
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133482/
https://ncbi.nlm.nih.gov/pubmed/24986688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-10-535245
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