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Exploring the Substrate Range of Wild-type Aminoacyl-tRNA Synthetases

We tested the substrate range of four wild-type Escherichia coli aminoacyl-tRNA synthetases (AARSs) with a library of non-standard amino acids (nsAAs). While these AARSs could discriminate efficiently against the other canonical amino acids, they were able to use many nsAAs as substrates. Our result...

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Detalhes bibliográficos
Main Authors: Fan, Chenguang, Ho, Joanne M.L., Chirathivat, Napon, Söll, Dieter, Wang, Yane-Shih
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133344/
https://ncbi.nlm.nih.gov/pubmed/24890918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402083
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