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Prodrug Strategy to Achieve Lyophilizable, High Drug Loading Micelle Formulations Through Diester Derivatives of β-Lapachone
β-Lap prodrug micelle strategy improve the formulation properties of β-lap therapeutics. The resulting micelles yielded apparent high β-lap solubility (>7 mg/mL), physical stability, and ability to reconstitute after lyophilization. In the presence of esterase, β-lap prodrugs were efficiently con...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4133338/ https://ncbi.nlm.nih.gov/pubmed/24532286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201300590 |
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