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Mixed oligomers and monomeric Amyloid-β disrupts endothelial cells integrity and reduces monomeric amyloid-β transport across hCMEC/D3 cell line as an in vitro blood-brain barrier model

Senile amyloid plaques are one of the diagnostic hallmarks of Alzheimer’s disease (AD). However, the severity of clinical symptoms of AD is weakly correlated with the plaque load. AD symptoms severity is reported to be more strongly correlated with the level of soluble amyloid-β (Aβ) assemblies. For...

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Bibliografiske detaljer
Main Authors: Qosa, Hisham, LeVine, Harry, Keller, Jeffrey N., Kaddoumi, Amal
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133170/
https://ncbi.nlm.nih.gov/pubmed/24997450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2014.06.029
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