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Mixed oligomers and monomeric Amyloid-β disrupts endothelial cells integrity and reduces monomeric amyloid-β transport across hCMEC/D3 cell line as an in vitro blood-brain barrier model

Senile amyloid plaques are one of the diagnostic hallmarks of Alzheimer’s disease (AD). However, the severity of clinical symptoms of AD is weakly correlated with the plaque load. AD symptoms severity is reported to be more strongly correlated with the level of soluble amyloid-β (Aβ) assemblies. For...

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書誌詳細
主要な著者: Qosa, Hisham, LeVine, Harry, Keller, Jeffrey N., Kaddoumi, Amal
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133170/
https://ncbi.nlm.nih.gov/pubmed/24997450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2014.06.029
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