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A Bead-based Normalization for Uniform Sequencing depth (BeNUS) protocol for multi-samples sequencing exemplified by HLA-B

BACKGROUND: Human leukocyte antigen (HLA) is a group of genes that are extremely polymorphic among individuals and populations and have been associated with more than 100 different diseases and adverse drug effects. HLA typing is accordingly an important tool in clinical application, medical researc...

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Bibliografiske detaljer
Main Authors: Hosomichi, Kazuyoshi, Mitsunaga, Shigeki, Nagasaki, Hideki, Inoue, Ituro
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133082/
https://ncbi.nlm.nih.gov/pubmed/25087472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-645
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