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Phase-defined complete sequencing of the HLA genes by next-generation sequencing

BACKGROUND: The human leukocyte antigen (HLA) region, the 3.8-Mb segment of the human genome at 6p21, has been associated with more than 100 different diseases, mostly autoimmune diseases. Due to the complex nature of HLA genes, there are difficulties in elucidating complete HLA gene sequences espec...

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Detalhes bibliográficos
Main Authors: Hosomichi, Kazuyoshi, Jinam, Timothy A, Mitsunaga, Shigeki, Nakaoka, Hirofumi, Inoue, Ituro
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671147/
https://ncbi.nlm.nih.gov/pubmed/23714642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-14-355
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