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A Bead-based Normalization for Uniform Sequencing depth (BeNUS) protocol for multi-samples sequencing exemplified by HLA-B

BACKGROUND: Human leukocyte antigen (HLA) is a group of genes that are extremely polymorphic among individuals and populations and have been associated with more than 100 different diseases and adverse drug effects. HLA typing is accordingly an important tool in clinical application, medical researc...

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Autors principals: Hosomichi, Kazuyoshi, Mitsunaga, Shigeki, Nagasaki, Hideki, Inoue, Ituro
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133082/
https://ncbi.nlm.nih.gov/pubmed/25087472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-645
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