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Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA.

p53 is a negative regulator of cell growth. The majority of human tumors express mutant p53 proteins, which can be distinguished from wild-type by their immuno-reactivity to a panel of conformation-specific monoclonal antibodies, such as PAb421, PAb1620 and PAb246. Wild-type p53 has sequence-specifi...

詳細記述

保存先:
書誌詳細
主要な著者: Halazonetis, T D, Davis, L J, Kandil, A N
フォーマット: Artigo
言語:Inglês
出版事項: 1993
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC413303/
https://ncbi.nlm.nih.gov/pubmed/8458320
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