Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53

Sequence-specific binding by the human p53 master regulator is critical to its tumor suppressor activity in response to environmental stresses. p53 binds as a tetramer to two decameric half-sites separated by 0–13 nucleotides (nt), originally defined by the consensus RRRCWWGYYY (n = 0–13) RRRCWWGYYY...

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Bibliographic Details
Main Authors: Jordan, Jennifer J., Menendez, Daniel, Inga, Alberto, Nourredine, Maher, Bell, Douglas, Resnick, Michael A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518093/
https://ncbi.nlm.nih.gov/pubmed/18714371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000104
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