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Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53
Sequence-specific binding by the human p53 master regulator is critical to its tumor suppressor activity in response to environmental stresses. p53 binds as a tetramer to two decameric half-sites separated by 0–13 nucleotides (nt), originally defined by the consensus RRRCWWGYYY (n = 0–13) RRRCWWGYYY...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2518093/ https://ncbi.nlm.nih.gov/pubmed/18714371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000104 |
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