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Reprogramming the Mechanism of Action of Chlorambucil by Coupling to a G-Quadruplex Ligand
[Image: see text] The nitrogen mustard Chlorambucil (Chl) generates covalent adducts with double-helical DNA and inhibits cell proliferation. Among these adducts, interstrand cross-links (ICLs) are the most toxic, as they stall replication by generating DNA double strand breaks (DSBs). Conversely, i...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4132976/ https://ncbi.nlm.nih.gov/pubmed/24697838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja5014344 |
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