The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions

Decitabine (5-aza-2′-deoxycytidine, 5-azadC) is used in the treatment of Myelodysplatic syndrome (MDS) and Acute Myeloid Leukemia (AML). Its mechanism of action is thought to involve reactivation of genes implicated in differentiation and transformation, as well as induction of DNA damage by trappin...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Orta, Manuel Luis, Höglund, Andreas, Calderón-Montaño, José Manuel, Domínguez, Inmaculada, Burgos-Morón, Estefanía, Visnes, Torkild, Pastor, Nuria, Ström, Cecilia, López-lázaro, Miguel, Helleday, Thomas
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2014
Sujets:
Genome Integrity, Repair and Replication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132747/
https://ncbi.nlm.nih.gov/pubmed/25074383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku638
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires