5-Aza-2′-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair

5-Aza-2′-deoxycytidine (5-azadC) is a DNA methyltransferase (DNMT) inhibitor increasingly used in treatments of hematological diseases and works by being incorporated into DNA and trapping DNMT. It is unclear what DNA lesions are caused by 5-azadC and if such are substrates for DNA repair. Here, we...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Orta, Manuel Luís, Calderón-Montaño, José Manuel, Domínguez, Inmaculada, Pastor, Nuria, Burgos-Morón, Estefanía, López-Lázaro, Miguel, Cortés, Felipe, Mateos, Santiago, Helleday, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675485/
https://ncbi.nlm.nih.gov/pubmed/23609537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt270
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados