The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions

Decitabine (5-aza-2′-deoxycytidine, 5-azadC) is used in the treatment of Myelodysplatic syndrome (MDS) and Acute Myeloid Leukemia (AML). Its mechanism of action is thought to involve reactivation of genes implicated in differentiation and transformation, as well as induction of DNA damage by trappin...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Orta, Manuel Luis, Höglund, Andreas, Calderón-Montaño, José Manuel, Domínguez, Inmaculada, Burgos-Morón, Estefanía, Visnes, Torkild, Pastor, Nuria, Ström, Cecilia, López-lázaro, Miguel, Helleday, Thomas
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2014
Aiheet:
Genome Integrity, Repair and Replication
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132747/
https://ncbi.nlm.nih.gov/pubmed/25074383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku638
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