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DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal
We previously identified the heterogeneous ribonucleoprotein SAF-A/hnRNP U as a substrate for DNA-PK, a protein kinase involved in DNA damage response (DDR). Using laser micro-irradiation in human cells, we report here that SAF-A exhibits a two-phase dynamics at sites of DNA damage, with a rapid and...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4132723/ https://ncbi.nlm.nih.gov/pubmed/25030905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku601 |
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