Molecular basis of nucleotide-dependent substrate engagement and remodeling by an AAA+ activator

Binding and hydrolysis of ATP is universally required by AAA+ proteins to underpin their mechano-chemical work. Here we explore the roles of the ATPase site in an AAA+ transcriptional activator protein, the phage shock protein F (PspF), by specifically altering the Walker B motif sequence required i...

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Detalhes bibliográficos
Main Authors: Darbari, Vidya C., Lawton, Ed, Lu, Duo, Burrows, Patricia C., Wiesler, Simone, Joly, Nicolas, Zhang, Nan, Zhang, Xiaodong, Buck, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132715/
https://ncbi.nlm.nih.gov/pubmed/25063294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku588
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