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A dual switch controls bacterial enhancer-dependent transcription
Bacterial RNA polymerases (RNAPs) are targets for antibiotics. Myxopyronin binds to the RNAP switch regions to block structural rearrangements needed for formation of open promoter complexes. Bacterial RNAPs containing the major variant σ(54) factor are activated by enhancer-binding proteins (bEBPs)...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3505966/ https://ncbi.nlm.nih.gov/pubmed/22965125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks844 |
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