Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation.

Lignende værker

• Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides.
  af: Bibbins, K B, et al.
  Udgivet: (1993)
• Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.
  af: Ladbury, J E, et al.
  Udgivet: (1995)
• Phosphopeptide binding to the N-terminal SH2 domain of the p85 alpha subunit of PI 3'-kinase: a heteronuclear NMR study.
  af: Hensmann, M., et al.
  Udgivet: (1994)
• Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase.
  af: Prasad, K V, et al.
  Udgivet: (1993)
• SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange.
  af: Felder, S, et al.
  Udgivet: (1993)