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Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation.

SH2 (src-homology 2) domains define a newly recognized binding motif that mediates the physical association of target phosphotyrosyl proteins with downstream effector enzymes. An example of such phosphoprotein-effector coupling is provided by the association of phosphatidylinositol 3-kinase (PI 3-ki...

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Библиографические подробности
Главные авторы: Shoelson, S E, Sivaraja, M, Williams, K P, Hu, P, Schlessinger, J, Weiss, M A
Формат: Artigo
Язык:Inglês
Опубликовано: 1993
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC413268/
https://ncbi.nlm.nih.gov/pubmed/8382612
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