Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation.

SH2 (src-homology 2) domains define a newly recognized binding motif that mediates the physical association of target phosphotyrosyl proteins with downstream effector enzymes. An example of such phosphoprotein-effector coupling is provided by the association of phosphatidylinositol 3-kinase (PI 3-ki...

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Detalles Bibliográficos

Publicado en:	EMBO J
Principais autores:	Shoelson, S E, Sivaraja, M, Williams, K P, Hu, P, Schlessinger, J, Weiss, M A
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Publishing Group 1993
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413268/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8382612/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb05714.x
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