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Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation.

SH2 (src-homology 2) domains define a newly recognized binding motif that mediates the physical association of target phosphotyrosyl proteins with downstream effector enzymes. An example of such phosphoprotein-effector coupling is provided by the association of phosphatidylinositol 3-kinase (PI 3-ki...

詳細記述

保存先:
書誌詳細
主要な著者: Shoelson, S E, Sivaraja, M, Williams, K P, Hu, P, Schlessinger, J, Weiss, M A
フォーマット: Artigo
言語:Inglês
出版事項: 1993
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC413268/
https://ncbi.nlm.nih.gov/pubmed/8382612
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