Functional Balance between the Hemagglutinin and Neuraminidase of Influenza A(H1N1)pdm09 HA D222 Variants

D222G/N substitutions in A(H1N1)pdm09 hemagglutinin may be associated with increased binding of viruses causing low respiratory tract infections and human pathogenesis. We assessed the impact of such substitutions on the balance between hemagglutinin binding and neuraminidase cleavage, viral growth...

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Hauptverfasser: Casalegno, Jean-Sébastien, Ferraris, Olivier, Escuret, Vanessa, Bouscambert, Maude, Bergeron, Corinne, Linès, Laetitia, Excoffier, Thierry, Valette, Martine, Frobert, Emilie, Pillet, Sylvie, Pozzetto, Bruno, Lina, Bruno, Ottmann, Michèle
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131921/
https://ncbi.nlm.nih.gov/pubmed/25119465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104009
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