A Novel I221L Substitution in Neuraminidase Confers High-Level Resistance to Oseltamivir in Influenza B Viruses

Influenza B viruses with a novel I221L substitution in neuraminidase (NA) conferring high-level resistance to oseltamivir were isolated from an immunocompromised patient after prolonged oseltamivir treatment. Methods. Enzymatic characterization of the NAs (Km, Ki) and the in vitro fitness of viruses...

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Bibliografische gegevens
Hoofdauteurs: Escuret, Vanessa, Collins, Patrick J., Casalegno, Jean-Sébastien, Vachieri, Sebastien G., Cattle, Nicholas, Ferraris, Olivier, Sabatier, Murielle, Frobert, Emilie, Caro, Valérie, Skehel, John J., Gamblin, Steve, Valla, Frédéric, Valette, Martine, Ottmann, Michèle, McCauley, John W., Daniels, Rodney S., Lina, Bruno
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2014
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Major Articles and Brief Reports
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176448/
https://ncbi.nlm.nih.gov/pubmed/24795482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu244
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