A Novel I221L Substitution in Neuraminidase Confers High-Level Resistance to Oseltamivir in Influenza B Viruses

Influenza B viruses with a novel I221L substitution in neuraminidase (NA) conferring high-level resistance to oseltamivir were isolated from an immunocompromised patient after prolonged oseltamivir treatment. Methods. Enzymatic characterization of the NAs (Km, Ki) and the in vitro fitness of viruses...

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Tallennettuna:
Bibliografiset tiedot
Päätekijät: Escuret, Vanessa, Collins, Patrick J., Casalegno, Jean-Sébastien, Vachieri, Sebastien G., Cattle, Nicholas, Ferraris, Olivier, Sabatier, Murielle, Frobert, Emilie, Caro, Valérie, Skehel, John J., Gamblin, Steve, Valla, Frédéric, Valette, Martine, Ottmann, Michèle, McCauley, John W., Daniels, Rodney S., Lina, Bruno
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2014
Aiheet:
Major Articles and Brief Reports
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176448/
https://ncbi.nlm.nih.gov/pubmed/24795482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu244
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