A Novel I221L Substitution in Neuraminidase Confers High-Level Resistance to Oseltamivir in Influenza B Viruses

Influenza B viruses with a novel I221L substitution in neuraminidase (NA) conferring high-level resistance to oseltamivir were isolated from an immunocompromised patient after prolonged oseltamivir treatment. Methods. Enzymatic characterization of the NAs (Km, Ki) and the in vitro fitness of viruses...

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Detaylı Bibliyografya
Asıl Yazarlar: Escuret, Vanessa, Collins, Patrick J., Casalegno, Jean-Sébastien, Vachieri, Sebastien G., Cattle, Nicholas, Ferraris, Olivier, Sabatier, Murielle, Frobert, Emilie, Caro, Valérie, Skehel, John J., Gamblin, Steve, Valla, Frédéric, Valette, Martine, Ottmann, Michèle, McCauley, John W., Daniels, Rodney S., Lina, Bruno
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2014
Konular:
Major Articles and Brief Reports
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176448/
https://ncbi.nlm.nih.gov/pubmed/24795482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu244
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