Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis.

We have investigated the mechanisms responsible for the sudden activation of the cdc2-cyclin B protein kinase before mitosis. It has been found previously that cdc25 is the tyrosine phosphatase responsible for dephosphorylating and activating cdc2-cyclin B. In Xenopus eggs and early embryos a cdc25...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Hoffmann, I, Clarke, P R, Marcote, M J, Karsenti, E, Draetta, G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413175/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8428594/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb05631.x
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