RNF4-Dependent Hybrid SUMO-Ubiquitin Chains are Signals for RAP80 and thereby Mediate the Recruitment of BRCA1 to Sites of DNA Damage

The DNA repair function of the breast cancer susceptibility protein BRCA1 depends in part on its interaction with RAP80, which targets BRCA1 to DNA double strand breaks (DSBs) through recognition of K63-linked polyubiquitin chains. The localization of BRCA1 to DSBs also requires sumoylation. Here, w...

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Bibliographic Details
Main Authors: Guzzo, Catherine M., Berndsen, Christopher E., Zhu, Jianmei, Gupta, Vibhor, Datta, Ajit, Greenberg, Roger A., Wolberger, Cynthia, Matunis, Michael J.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131685/
https://ncbi.nlm.nih.gov/pubmed/23211528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003485
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