RNF4-Dependent Hybrid SUMO-Ubiquitin Chains are Signals for RAP80 and thereby Mediate the Recruitment of BRCA1 to Sites of DNA Damage

The DNA repair function of the breast cancer susceptibility protein BRCA1 depends in part on its interaction with RAP80, which targets BRCA1 to DNA double strand breaks (DSBs) through recognition of K63-linked polyubiquitin chains. The localization of BRCA1 to DSBs also requires sumoylation. Here, w...

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Main Authors: Guzzo, Catherine M., Berndsen, Christopher E., Zhu, Jianmei, Gupta, Vibhor, Datta, Ajit, Greenberg, Roger A., Wolberger, Cynthia, Matunis, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131685/
https://ncbi.nlm.nih.gov/pubmed/23211528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003485
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