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Rap80 Protein Recruitment to DNA Double-strand Breaks Requires Binding to Both Small Ubiquitin-like Modifier (SUMO) and Ubiquitin Conjugates

Ubiquitin (Ub) modifications at sites of DNA double-strand breaks (DSBs) play critical roles in the assembly of signaling and repair proteins. The Ub-interacting motif (UIM) domain of Rap80, which is a component of the BRCA1-A complex, interacts with Ub Lys-63 linkage conjugates and mediates the rec...

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Detaylı Bibliyografya
Asıl Yazarlar: Hu, Xin, Paul, Atanu, Wang, Bin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408150/
https://ncbi.nlm.nih.gov/pubmed/22689573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.374116
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