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RAP80 Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites

Mutations affecting the BRCT domains of the breast cancer–associated tumor suppressor BRCA1 disrupt the recruitment of this protein to DNA double-strand breaks (DSBs). The molecular structures at DSBs recognized by BRCA1 are presently unknown. We report the interaction of the BRCA1 BRCT domain with...

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書誌詳細
主要な著者: Sobhian, Bijan, Shao, Genze, Lilli, Dana R., Culhane, Aedín C., Moreau, Lisa A., Xia, Bing, Livingston, David M., Greenberg, Roger A.
フォーマット: Artigo
言語:Inglês
出版事項: 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706583/
https://ncbi.nlm.nih.gov/pubmed/17525341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1139516
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