Sp1 functions in a chromatin-dependent manner to augment human alpha-globin promoter activity.

The 5' flanking region of the human alpha-globin gene is highly G + C rich and contains multiple copies of the consensus sequence for the Sp1 binding site. We investigated the role of this G + C-rich region in augmenting alpha-globin promoter activity in the presence of the far-upstream alpha-globin...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Pondel, M D, Murphy, S, Pearson, L, Craddock, C, Proudfoot, N J
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1995
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41314/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7638173/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.16.7237
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