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Substitution of the Human β-Spectrin Promoter for the Human (A)γ-Globin Promoter Prevents Silencing of a Linked Human β-Globin Gene in Transgenic Mice

During development, changes occur in both the sites of erythropoiesis and the globin genes expressed at each developmental stage. Previous work has shown that high-level expression of human β-like globin genes in transgenic mice requires the presence of the locus control region (LCR). Models of hemo...

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Autors principals: Sabatino, Denise E., Cline, Amanda P., Gallagher, Patrick G., Garrett, Lisa J., Stamatoyannopoulos, George, Forget, Bernard G., Bodine, David M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC109248/
https://ncbi.nlm.nih.gov/pubmed/9774678
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