Substitution of the Human β-Spectrin Promoter for the Human (A)γ-Globin Promoter Prevents Silencing of a Linked Human β-Globin Gene in Transgenic Mice

During development, changes occur in both the sites of erythropoiesis and the globin genes expressed at each developmental stage. Previous work has shown that high-level expression of human β-like globin genes in transgenic mice requires the presence of the locus control region (LCR). Models of hemo...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Sabatino, Denise E., Cline, Amanda P., Gallagher, Patrick G., Garrett, Lisa J., Stamatoyannopoulos, George, Forget, Bernard G., Bodine, David M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1998
Assuntos:	Transcriptional Regulation
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109248/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9774678/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.11.6634
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