Camkii-Dependent Phosphorylation of Cardiac Ryanodine Receptors Regulates Cell Death In Cardiac Ischemia/Reperfusion Injury

Ca(2+)-Calmodulin kinase II (CaMKII) activation is deleterious in cardiac ischemia/reperfusion (I/R). Moreover, inhibition of CaMKII-dependent phosphorylations at the sarcoplasmic reticulum (SR) prevents CaMKII-induced I/R damage. However, the downstream targets of CaMKII at the SR level, responsibl...

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Detalhes bibliográficos
Main Authors: Di Carlo, Mariano N., Said, Matilde, Ling, Haiyun, Valverde, Carlos A., De Giusti, Verónica, Sommese, Leandro, Palomeque, Julieta, Aiello, Alejandro E., Skapura, Darlene G., Rinaldi, Gustavo, Respress, Jonathan L., Brown, Joan Heller, Wehrens, Xander H.T., Salas, Margarita A., Mattiazzi, Alicia
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131282/
https://ncbi.nlm.nih.gov/pubmed/24949568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.06.004
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