Ryanodine Receptor Phosphorylation by CaMKII Promotes Spontaneous Ca(2+) Release Events in a Rodent Model of Early Stage Diabetes: the Arrhythmogenic Substrate

BACKGROUND: Heart failure and arrhythmias occur more frequently in patients with type 2 diabetes (T2DM) than in the general population. T2DM is preceded by a prediabetic condition marked by elevated reactive oxygen species (ROS) and subclinical cardiovascular defects. Although multifunctional Ca(2+)...

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Publicado en:Int J Cardiol
Main Authors: Sommese, Leandro, Valverde, Carlos A, Blanco, Paula, Castro, María Cecilia, Rueda, Omar Velez, Kaetzel, Marcia, Dedman, John, Anderson, Mark E., Mattiazzi, Alicia, Palomeque, Julieta
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872299/
https://ncbi.nlm.nih.gov/pubmed/26432489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijcard.2015.09.022
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