Influence of a dual-injection regimen, plerixafor, and CXCR4 on in-utero hematopoietic stem cell transplantation and engraftment using the sheep model

BACKGROUND: Inadequate engraftment of hematopoietic stem cells (HSCs) following in-utero HSC transplantation (IUHSCT) remains a major obstacle for the prenatal correction of numerous hereditary disorders. HSCs express CXCR4 receptors that allow homing and engraftment in response to SDF1 ligand prese...

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Autori principali: Goodrich, A. Daisy, Varain, Nicole M., Jeanblanc, Christine M., Colon, Donna M., Kim, Jaehyup, Zanjani, Esmail D., Hematti, Peiman
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131210/
https://ncbi.nlm.nih.gov/pubmed/25108653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcyt.2014.05.025
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