Oestrogen receptor-alpha regulates non-canonical Hedgehog-signalling in the mammary gland

Mesenchymal dysplasia (mes) mice harbour a truncation in the C-terminal region of the Hh-ligand receptor, Patched-1 (mPtch1). While the mes variant of mPtch1 binds to Hh-ligands with an affinity similar to that of wild type mPtch1 and appears to normally regulate canonical Hh-signalling via smoothen...

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Bibliographic Details
Main Authors: Okolowsky, Nadia, Furth, Priscilla A., Hamel, Paul A.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131199/
https://ncbi.nlm.nih.gov/pubmed/24769368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2014.04.007
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