The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele

p53 loss of heterozygosity (p53LOH) is frequently observed in Li-Fraumeni syndrome (LFS) patients who carry a mutant (Mut) p53 germ-line mutation. Here, we focused on elucidating the link between p53LOH and tumor development in stem cells (SCs). Although adult mesenchymal stem cells (MSCs) robustly...

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Detaylı Bibliyografya
Asıl Yazarlar: Shetzer, Y, Kagan, S, Koifman, G, Sarig, R, Kogan-Sakin, I, Charni, M, Kaufman, T, Zapatka, M, Molchadsky, A, Rivlin, N, Dinowitz, N, Levin, S, Landan, G, Goldstein, I, Goldfinger, N, Pe'er, D, Radlwimmer, B, Lichter, P, Rotter, V, Aloni-Grinstein, R
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2014
Konular:
Original Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131174/
https://ncbi.nlm.nih.gov/pubmed/24832469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.57
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