The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele

p53 loss of heterozygosity (p53LOH) is frequently observed in Li-Fraumeni syndrome (LFS) patients who carry a mutant (Mut) p53 germ-line mutation. Here, we focused on elucidating the link between p53LOH and tumor development in stem cells (SCs). Although adult mesenchymal stem cells (MSCs) robustly...

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Bibliografiska uppgifter
Huvudupphovsmän: Shetzer, Y, Kagan, S, Koifman, G, Sarig, R, Kogan-Sakin, I, Charni, M, Kaufman, T, Zapatka, M, Molchadsky, A, Rivlin, N, Dinowitz, N, Levin, S, Landan, G, Goldstein, I, Goldfinger, N, Pe'er, D, Radlwimmer, B, Lichter, P, Rotter, V, Aloni-Grinstein, R
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2014
Ämnen:
Original Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131174/
https://ncbi.nlm.nih.gov/pubmed/24832469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.57
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