Mechanism of the Rpn13-induced activation of Uch37

Uch37 is a de-ubiquitinating enzyme that is activated by Rpn13 and involved in the proteasomal degradation of proteins. The full-length Uch37 was shown to exhibit low iso-peptidase activity and is thought to be auto-inhibited. Structural comparisons revealed that within a homo-dimer of Uch37, each o...

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Hlavní autoři: Jiao, Lianying, Ouyang, Songying, Shaw, Neil, Song, Gaojie, Feng, Yingang, Niu, Fengfeng, Qiu, Weicheng, Zhu, Hongtao, Hung, Li-Wei, Zuo, Xiaobing, Eleonora Shtykova, V., Zhu, Ping, Dong, Yu-Hui, Xu, Ruxiang, Liu, Zhi-Jie
Médium: Artigo
Jazyk:Inglês
Vydáno: Higher Education Press 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130924/
https://ncbi.nlm.nih.gov/pubmed/24752541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-014-0046-z
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