Hydrochlorothiazide-induced hyperuricaemia in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) study

OBJECTIVE: Elevations in uric acid (UA) and the associated hyperuricaemia are commonly observed secondary to treatment with thiazide diuretics. We sought to identify novel single-nucleotide polymorphisms (SNPs) associated with hydrochlorothiazide (HCTZ)-induced elevations in UA and hyperuricaemia. M...

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Autori principali: Vandell, Alexander G., McDonough, Caitrin W., Gong, Yan, Langaee, Taimour Y., Lucas, Anne M., Chapman, Arlene B., Gums, John G., Beitelshees, Amber L., Bailey, Kent R., Johnson, Richard J., Boerwinkle, Eric, Turner, Stephen T., Cooper-DeHoff, Rhonda M., Johnson, Julie A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130802/
https://ncbi.nlm.nih.gov/pubmed/24612202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/joim.12215
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