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Essential role for mevalonate synthesis in DNA replication

The relationship between 3-hydroxy-3-methylglutaryl (HMG) CoA reductase activity [mevalonate:NADP(+) oxidoreductase (CoA-acylating), EC 1.1.1.34] and DNA synthesis was studied in synchronized cultures of BHK-21 cells. During a 24-hr period of cell replication, two phases of accelerated thymidine inc...

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Main Authors: Quesney-Huneeus, Valeria, Wiley, Millie Hughes, Siperstein, Marvin D.
Formato: Artigo
Idioma:Inglês
Publicado: 1979
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC413078/
https://ncbi.nlm.nih.gov/pubmed/291922
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