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The effect of mevalonic acid deprivation on enzymes of DNA replication in cells emerging from quiescence.

We have investigated the biochemical basis of the mevalonate dependence of DNA replication. Stimulating quiescent rat hepatoma cells to proliferate in the presence of compactin, an inhibitor of mevalonate synthesis, prevented DNA replication in as many as 80% of these cells. The percentage of cells...

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Detalhes bibliográficos
Main Authors: Silber, J R, Galick, H, Wu, J M, Siperstein, M D
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1131969/
https://ncbi.nlm.nih.gov/pubmed/1281982
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