Structure of a Stapled Peptide Antagonist Bound to Nutlin-Resistant Mdm2

As key negative regulator of the p53 tumour suppressor, Mdm2 is an attractive therapeutic target. Small molecules such as Nutlin have been developed to antagonise Mdm2, resulting in p53-dependent death of tumour cells. We have recently described a mutation in Mdm2 (M62A), which precludes binding of...

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Autors principals: Chee, Sharon Min Qi, Wongsantichon, Jantana, Soo Tng, Quah, Robinson, Robert, Joseph, Thomas L., Verma, Chandra, Lane, David P., Brown, Christopher J., Ghadessy, Farid J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130638/
https://ncbi.nlm.nih.gov/pubmed/25115702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104914
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