The Pancreatic Islet Beta Cell-Enriched Transcription Factor Pdx-1 Regulates Slc30a8 Gene Transcription Through an Intronic Enhancer

The SLC30A8 gene encodes the zinc transporter ZnT-8, which provides zinc for insulin-hexamer formation. Genome-wide association studies have shown that a polymorphic variant in SLC30A8 is associated with altered susceptibility to type 2 diabetes and we recently reported that glucose-stimulated insul...

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Détails bibliographiques
Auteurs principaux: Pound, Lynley D., Hang, Yan, Sarkar, Suparna A., Wang, Yingda, Milam, Laurel A., Oeser, James K., Printz, Richard L., Lee, Catherine E., Stein, Roland, Hutton, John C., O’Brien, Richard M.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130494/
https://ncbi.nlm.nih.gov/pubmed/20942803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20101488
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