Deletion of the G6pc2 Gene Encoding the Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Does Not Affect the Progression or Incidence of Type 1 Diabetes in NOD/ShiLtJ Mice

OBJECTIVE: Islet-specific glucose-6-phosphatase catalytic subunit–related protein (IGRP), now known as G6PC2, is a major target of autoreactive T cells implicated in the pathogenesis of type 1 diabetes in both mice and humans. This study aimed to determine whether suppression of G6p2 gene expression...

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Detaylı Bibliyografya
Asıl Yazarlar: Oeser, James K., Parekh, Vrajesh V., Wang, Yingda, Jegadeesh, Naresh K., Sarkar, Suparna A., Wong, Randall, Lee, Catherine E., Pound, Lynley D., Hutton, John C., Van Kaer, Luc, O’Brien, Richard M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Diabetes Association 2011
Konular:
Immunology and Transplantation
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198073/
https://ncbi.nlm.nih.gov/pubmed/21896930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0220
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