Deletion of the G6pc2 Gene Encoding the Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Does Not Affect the Progression or Incidence of Type 1 Diabetes in NOD/ShiLtJ Mice

OBJECTIVE: Islet-specific glucose-6-phosphatase catalytic subunit–related protein (IGRP), now known as G6PC2, is a major target of autoreactive T cells implicated in the pathogenesis of type 1 diabetes in both mice and humans. This study aimed to determine whether suppression of G6p2 gene expression...

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Hauptverfasser: Oeser, James K., Parekh, Vrajesh V., Wang, Yingda, Jegadeesh, Naresh K., Sarkar, Suparna A., Wong, Randall, Lee, Catherine E., Pound, Lynley D., Hutton, John C., Van Kaer, Luc, O’Brien, Richard M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2011
Schlagworte:
Immunology and Transplantation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198073/
https://ncbi.nlm.nih.gov/pubmed/21896930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0220
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